I love the comic XKCD. I have a dream that one day an epic movie based on it will be made. I suspect that to be true to the original, it would have to consist of a series of short vignettes, only some of which have continuity.
As well as the overarching themes of "romance, sarcasm, math and language" it would have to have sudden adventure, geeks, physics, love, dreams, surreal imagery, raptors, red spiders, lisp, dadaism, algorithms, tin apples, meat cereals, wikipedia, "your mom" jokes, references to Richards Feynman and Stallman, and quite possibly the the map of all ideas that anyone has ever had.
It would be truly awesome. But it's probably even more awesome in my imagination than it would be in reality.